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HTTP > Advanced Threat Protection > Policies and then open the Virus Scan Rule tab after Adding or edit an existing policy
All scannable files: For maximum security, Trend Micro recommends that you scan all scannable file types. MORE>>
IntelliScan: Choose this option to scan only those files types known to be susceptible to viruses. MORE>>
Specific file extensions: This option is potentially the least secure, but does offer the fastest scanning performance. MORE>>
MIME content-type to skip: You can prevent IWSVA from scanning certain MIME content types. This may be necessary, for example, if scanning interferes with the delivery of real-time streaming content such as RealPlayer or the Microsoft download manager. MORE>>